The Children’s Cancer Research Institute - CCRI (St. Anna Kinderkrebsforschung) is Austria’s leading center for research aimed at advancing the diagnosis and treatment of children’s cancer. It pursues an ambitious basic, translational and clinical research program, including areas such as cancer biology, immunology, and genetics/epigenetics CCRI is part of a flourishing biomedical research hub at the heart of Vienna. It is a renowned research institution with tight links to the St. Anna Children’s Hospital, a leading pediatric cancer center in Europe that is internationally well-connected through European and global networks.
The focus of our group (lead by Prof. Kaan Boztug) is to identify novel gene defects that lead to rare disorders of the immune system and to further functionally analyze their impact on the severe pathophysiologic manifestations in patients. (Kager L et al. Br J Haematol. 2018, Ozen A et al. NEJM 2017, Salzer E et al. Nat Immunol 2016, Dobbs K et al. NEJM 2015, Boztug K at al. Nat Genet 2014). In addition, we are establishing a research program on precision oncology medicine focusing on childhood cancer.
In the context of this work, we apply a combination of state-of-the-art genetic and genomic technologies including next generation sequencing, and a wide range of cellular and molecular techniques to elucidate novel pathways important for immune system homeostasis.
We are looking for a highly motivated and well-organized
with a strong interest in genetics and research of rare and undiagnosed diseases. The candidate will be integrated into the genetics core of the institute with the emphasis on genomic technologies leading to identification of disease-causing mutations. In this position, you will substantially contribute to the infrastructure, operation of the lab and documentation. We have established a streamlined workflow for NGS-based genetic analyses that requires continuous maintenance and optimization as well as development and implementation of novel assays, tools and infrastructure.